Beta-glucans are biologically active polysaccharides known for their role in supporting immune health—but what many don’t realize is that not all beta-glucans are the same.
Each mushroom species produces structurally distinct beta-glucan molecules, with unique branching patterns that interact differently with the immune system. Turkey Tail, for example, is rich in 1,3/1,6 beta-glucans, closely studied for immune modulation. Lion’s Mane contains neuro-supportive compounds alongside its beta-glucans, while Antler Reishi offers a broad spectrum of adaptogenic triterpenes and immune-active polysaccharides.

At Tremetes, we preserve these natural differences by using only the whole fruiting body, cultivated in the U.S. and verified through third-party testing—so you get the real bioactive compounds, not just the marketing claims.

Polysaccharide-K (PSK), also known as Krestin, is one of the most extensively studied compounds found in Turkey Tail mushrooms. This unique protein-bound beta-glucan has been shown in clinical research to stimulate immune cell activity and support the body’s natural defense mechanisms.
PSK is especially well-known in Japan, where it has been used for decades as a prescription adjunct to cancer therapy, underscoring its credibility in integrative medicine. Its ability to modulate immune responses without overstimulation makes it a standout among mushroom-derived polysaccharides.

At Tremetes, we cultivate Turkey Tail with care to preserve the full spectrum of natural beta-glucans—including PSK—ensuring you receive the mushroom’s authentic immune-supportive potential.

Polysaccharide-Peptide (PSP) is another immune-active compound found in Turkey Tail mushrooms, structurally similar to PSK but with its own unique profile. Like PSK, PSP has drawn attention for its immune-modulating effects, particularly its ability to enhance the activity of natural killer (NK) cells and T-cells.
Scientific studies suggest that PSP may play a supportive role in integrative cancer care, helping the immune system better recognize and respond to abnormal cells. Its use in traditional and modern research contexts reflects a growing interest in how natural compounds can work in harmony with the body's innate defenses.

At Tremetes, our commitment to using the whole fruiting body means preserving these naturally occurring compounds—PSK, PSP, and a wide array of beta-glucans—so you experience Turkey Tail as nature intended.

Coriolan is a unique type of beta-glucan found specifically in Turkey Tail mushrooms (Trametes versicolor). Recognized for its immunostimulatory effects, Coriolan has been the subject of ongoing research exploring how it interacts with immune cells to support the body’s natural defense systems.
Its presence highlights the complexity and therapeutic potential of mushroom-derived polysaccharides, reinforcing why whole-fruiting-body Turkey Tail is valued in integrative wellness practices.

At Tremetes, our Turkey Tail retains the full spectrum of naturally occurring beta-glucans—including Coriolan—through careful cultivation and processing, without mycelium or grain-based dilution.

Hericenones are a class of naturally occurring compounds found in the fruiting body of Lion’s Mane (Hericium erinaceus). These unique aromatic compounds have been shown in scientific studies to stimulate nerve growth factor (NGF) synthesis—a protein essential for the growth, maintenance, and survival of neurons.

By supporting NGF production, hericenones are believed to play a role in:

• Neurogenesis (formation of new neurons)
• Cognitive function
• Memory and focus
• Protection against age-related neural decline

Unlike many products on the market that use mycelium—which contains little to no hericenones—Tremetes uses only the fruiting body, where these compounds naturally occur. Combined with naturally occurring beta-glucans, our Lion’s Mane offers a full-spectrum, no-filler, neuro-supportive mushroom in its purest form.

Antler Reishi (Ganoderma lucidum) is prized for its high concentration of triterpenes, a group of bioactive compounds responsible for many of Reishi’s most studied effects. These include ganoderic acids, lucidenic acids, and ganolucidic acids—compounds known for their ability to support balance and resilience in the body.

Triterpenes have been shown to:

• Modulate the body’s stress response and promote nervous system regulation
• Exhibit anti-inflammatory and antioxidant activity
• Support liver function and histamine response
• Influence immune signaling and cellular defense pathways (including early-stage tumor research)

The antler form of Reishi, grown under specific environmental stressors (low airflow, high CO₂), naturally produces a denser concentration of triterpenes than the traditional “conk” variety.

At Tremetes, we use only the fruiting body of antler Reishi, cultivated in the U.S. with no mycelium, fillers, or imported biomass.

If you’re looking for the true adaptogenic profile of Reishi, this is it—real antler Reishi, rich in triterpenes, no compromises.